Support is at the core of Bionet’s strategy, and this is a tangible example of it. Here you will find the resources that you need to push and enhance your bioprocess forward, as well as to feel part of its scientific community.
Expert ReferencesWe all know about the importance of having industry peers to share and discuss our experiences with. We are often aware of the things that we would like to do better but don’t have time to empirically test them and improve them. At Bionet we are aware of how important and rewarding finding the right advice at the right time can be. By clicking in this section you will get a selection of a series of White Papers by Bionet’s Experts, Collaborators and Clients on a variety of process experimental and operational issues.
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Details that MatterTechnology providers should commit to bring functional technologies to their users, but caring about the Details that Matter is not something that all providers are obliged and able to do. There are functional and design details that can make a world, and at Bionet we are constantly making a huge effort to spot them and integrate them into our products and our company culture. By clicking in this Details that Matter area, the publications to read and find out about them will be selected.
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Scientific AcademyThe bioprocess industry is at the moment a dynamic one, with many new bioprocesses coming in as well as others being at the spotlight for optimization. At Bionet we are constantly exploring new ways in which the bioprocess applications can find their highest potential, and as good scientists we need to support these words with data. By clicking in this section a selection of Scientific Publications by Bionet’s application specialists will be selected for you.
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Nice OffersWithin this world-changing industry there is also space for some fun, prizes and discount campaigns. Please click this section if you want to find out about any current offer and see if you are eligible for any of these.
The Continuous Process in the context of a bioreactor operation mode is used to prolong the production phase of a culture during its growth in a steady-state (at a constant rate and in constant conditions) to achieve higher biomass and/or metabolites amounts. There are two main process control strategies that can be implemented in Continuous Processing: the chemostat and the turbidostat methods.
Are you at the initial stages of your bioprocess development? Are you still unsure about whether your cells and/or target product will be better off with the homogenity given by a stirrer or the recirculation patterns created in an airlift bioreactor vessel?
Pichia pastoris has been successfully used as an efficient expression system for heterologous protein production.Herein, we report the development of a semicontinuous process to improve the production of recombinant proteins in P.pastoris by its cultivation in a BIONET’ s F1 benchtop bioreactor of 3 L equipped with a continuous process module(CPM). Six repetitive batches were conducted in a semicontinuous process by replacing 2 / 3 of the culture every 72-96 h.The overall process in a volume of 3 L of culture yielded a protein concentration of 0.28± 0.13 mg· mL-1, […]
The majority of microbial fermentations are performed in batch or fedbatch mode, further increasing energy consumption and steps, limiting the productivity, conducting high costs. In some cases, these limitations are based on the equipment and technologies available
Tangential Flow fitlration consists on the passage of the product feed in parallel to the surface of the filtering element/membrane . The most bioprocesses use surface-active agents to reduce the foam formation, widely known as antifoams, defoamers and defoaming agents among others.
The chemical cleaning of the ceramic and/or hollow fiber membranes after a filtration stage must receive the attention it deserves. Having defined an effective cleaning protocol is just as important as having optimized filtration conditions when dealing with a tangential flow filtration process in your downstream. Moreover, I would dare to say, the latter is even more important. If after filtering we do not clean properly, the permeability of the membranes will go down batch after batch, resulting in changes to the membranes prematurely and thereby increasing the cost. The “permeability” […]
It is widely agreed that the most important quality factor of a bioreactor is its capacity to keep its inside sterile throughout the whole process and despite the number of operational human interactions that will take part during such period, including sampling and harvesting steps. Therefore, it is widely assumed that a bioreactor will do its part in meeting this need by assuring that the technical factors that can affect sterility, such as the lip seals, the mechanical seals, the ports accessories, among many others, are well designed and working […]
When a continuous fermentation process is carried out, it is critical that the condition of steady-state must be reached. The main process parameters that can be used for the chemostat technique are the dilution rate, specific growth rate and the yield of the product on the substrate. The dilution rate (D), usually in units per hour (h−1), describes the relationship between the flow of medium into the bioreactor (F), that can be expressed in L·h−1, and culture volume within the bioreactor (V) in L Residence time (t) is the […]
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