Productivity enhancement of B. subtilis by cascade continuous fermentation
The majority of microbial fermentations are performed in batch or fedbatch mode, further increasing energy consumption and steps, limiting the productivity, conducting high costs. In some cases, these limitations are based on the equipment and technologies available [1]. The successful establishment of open production process based on continuous mode will lead to reducing the production […]
Bionet Continues Its Consolidation As A Leader In The Supply Of Complete Bioproduction Facilities
In Bionet’s trajectory a lot of the work and expertise has been developed around industrial scale projects, and 2017 has been a great year for this, with bioproduction plants put in place by Bionet for clients working in the monoclonal antibodies, animal vaccine and biocide production fields in three different European countries. As a representative example, Bionet has had the opportunity […]
Customization of agitation systems at its best
At BIONET, practical integration of knowledge derived from research as well as that gained from our clients’ experience happens on a continuous manner. This is vital to our evolution as a company and to the technological development and success of our products. An example of this is the effort that we deploy in adapting […]
Chemical cleaning of membranes
The chemical cleaning of the ceramic and/or hollow fiber membranes after a filtration stage must receive the attention it deserves. Having defined an effective cleaning protocol is just as important as having optimized filtration conditions when dealing with a tangential flow filtration process in your downstream. Moreover, I would dare to say, the latter is even more important. […]
Recombinant Protein Expression in P. pastoris in a bioreactor via a semicontinuous mode
Pichia pastoris has been successfully used as an efficient expression system for heterologous protein production.Herein, we report the development of a semicontinuous process to improve the production of recombinant proteins in P.pastoris by its cultivation in a BIONET’ s F1 benchtop bioreactor of 3 L equipped with a continuous process module(CPM). Six repetitive batches were conducted in a […]
Monoclonal Antibody Production
The core of the technological infrastructure required for biopharmaceutical manufacturing is the bioreactor, used in all stages from R&D to biomanufacturing. The F0-BABY bioreactor line by BIONET is comprised of robust and user-friendly laboratory bioreactor models that can be configured for different cell expression systems like microbial cultures or cell cultures. In the present work, […]
