Bioreactors
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Bioreactors
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Mixing type
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Applications
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Industry
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Turn your plant cell culture into a scalable bioprocess
Move into bioreactors, improve process performance, or expand production with Bionet. We combine plant cell expertise, upstream and downstream process development, process testing, and equipment engineering to help you evaluate feasibility before investing, address scale-up challenges, and overcome production bottlenecks from cultivation through recovery and purification.
Feasibility studies and bioreactor proof of concept
Controlled trials to improve growth, yield and reproducibility
Shear-aware transfer from benchtop to pilot and production
Simplify seed trains, reduce transfers, and improve production efficiency.
Our in-house plant cell specialist, Fuensanta Verdu Navarro, PhD, works alongside our scientists and engineers on culture-specific requirements, including shear sensitivity, oxygen transfer and cell aggregation.
At Bionet’s pilot plant, we can test your culture and evaluate process performance.
Evaluate equipment with your own process through trials, rental or demonstration options. Depending on the project, testing can take place at Bionet, a partner facility or your site.
When you’re ready, we’ll help you select the bioreactor configuration, automation and downstream systems that fit your operating requirements.
We contribute experimental work, bioreactor expertise, and engineering to joint projects with universities, research institutes, and companies.
Explore selected studies and applications involving Bionet bioreactors, developed through research and collaboration in plant cell bioprocessing.
Selecting the right bioreactor for plant cell culture
Plant cells present specific challenges, including shear sensitivity, aggregation and oxygen transfer. Co-authored by Bionet’s Bioprocessing R&D team, this review combines plant cell expertise and bioreactor engineering to explore how different bioreactor technologies can be adapted to culture and process requirements.
Improving plant cell growth through oxygen control
Slow growth can limit plant cell process productivity. Using Bionet F0 and F2 stirred-tank bioreactors, controlled agitation and aeration improved oxygen availability, reducing Nicotiana benthamiana cultivation time from 21 to 10 days and successfully transferring the process from 2 L to 7 L.
Moving plant cell production towards commercial scale
Taking plant cell cultures beyond the laboratory requires sufficient yield, consistency and scalable production. This review explores bioreactor-based production of food ingredients, natural colorants and bioactive compounds, highlighting the process challenges that must be addressed when moving towards commercial manufacturing.
Scaling plant-based protein production without losing yield
Scale-up can compromise the performance of promising plant-derived production processes. Using the Bionet CELL-tainer® CT2, this study scaled Nicotiana tabacum BY-2 cell-free protein production from microlitre volumes to 1 L, achieving a 20,000× scale-up without loss of protein yield.
