Upstream Bioprocesing

F2 Bioreactor

Pilot bioreactor for scale-up studies and production of small batches or inoculum for industrial productions

The models in the F2 series are the perfect solution for all those seeking for their first Steam In Place (SIP) stainless steel bioreactor/ fermenter for the scaling up of their bioprocesses and for small production applications. They are available in working volumes from 10 to 30 L.

the reference in the market

With a professional design and construction, which makes it the reference in the market, it integrates many extraordinary details to offer a user-friendly experience, ready to be easily integrated into your facilities.

jump!

How does the F2 help your bioprocess jump into an industrial arena?

PROCESS KNOWLEDGE
& CONTROL

Providing the possibility to integrate a complete range of instrumentation and actuators, and allowing all kinds of associated control strategies helps you to better understand and improve your processes.

Example of instruments which can be added beyond the standard configuration are: Pressure, Optical Density, Viable Cells, Dissolved CO2, Exhaust gas composition, Redox, Weight and many others.

Most of these instruments have a corresponding MARTA SW module. These specific SW modules allows the user to select parameter as part of your control strategies and gives additional calculated information (e.g. OTR or OUR) in real time.

INTEGRATED
CIP & SIP

The F2 can be delivered with integrated utilities (SIP and CIP) to help you to start your journey SIP Bioreactors in an easy way and with a minimal investment.

All in the same frame, with no extra-footprint. All controlled from our control SW MARTA with specific screens for complete control and programming of your Sterilization and Cleaning In Place Cycle.

For the CIP recipes can be created and saved to allow for standardization and productivity.

SIP & CIP

Gmp designed,
built & qualified

As all BIONET equipment and projects the F2 can be designed, built and qualified under GMP guidelines to allow the validation of your processes.

Our GMP approach is structured so it can be adapted to your specific project and regulatory needs. The upgrade from a standard unit to a GMP one will affect many issues on the design and construction:

Technologies, Calibrations, Documentation, Qualification and SW (including ER under CFR 21 c11).

DQ, IQ & OQ

MARTA CONTROL
SOFTWARE FOR
BIOPROCESSING

MARTA is the Automation SW which comes installed in the F2 units. In this model has off-the-shelve solutions for Cell Culture, Fermentation which can be expanded with additional modules for local SIP and CIP, new instrumentation or advanced gassing or dosing control.

TECHNICAL SPECIFICATIONS

MODEL F2 MB

MODEL F2 CC

general
general
AUTOCLAVE DIMENSIONS (W X H X D)
  • NA
AUTOCLAVE DIMENSIONS (W X H X D)
  • NA
MATERIAL
  • 316L SS in surfaces in contact with product
  • 304 SS in frame
MATERIAL
  • 316L SS in surfaces in contact with product
  • 304 SS in frame
MULTIBIOREACTOR
  • NA
MULTIBIOREACTOR
  • NA
TOTAL FOOTPRINT ON BENCH (W X H X D)
  • 1200 x 1993 x 740
TOTAL FOOTPRINT ON BENCH (W X H X D)
  • 1200 x 1993 x 740
vessel
vessel
Minimum Working Volume (L)
  • 6 (15L)
  • 12 (30L)
Minimum Working Volume (L)
  • 7 (15L)
  • 10.5 (30L)
Wall
  • Jacketed
Wall
  • Jacketed
Working volumes available
  • 15, 30
Working volumes available
  • 15, 30
agitation
agitation
Agitator
  • Top mounted
  • Single mechanical seal
  • Optional: double mechanical seal
Agitator
  • Top mounted
  • Standard: Single mechanical seal
  • Optional: double mechanical seal
Impellers
  • Optional: Marine/Pitched blade; or customised
  • Standard: 3x Rushton
Impellers
  • Standard: 1x Marine
  • Optional: customised (upon demand)
Motorpower
  • 0.6 kW (15L)
  • 1.1 kW (30L)
Motorpower
  • 0.37 kW (15L)
  • 0.6 kW (30L)
Speed (rpm)
  • 10-400
Speed (rpm)
  • 10-400
gassing module
gassing module
0.22 µm filter in gas lines
  • Included by default
0.22 µm filter in gas lines
  • Included by default
Condenser
  • Optional
Condenser
  • Optional
Filter at exhaust gas
  • Optional
Filter at exhaust gas
  • Optional
Gas flow control and gas mixture
  • Standard: manual via rotameters
  • Optional: automatic MFCs
Gas flow control and gas mixture
  • Standard: manual via rotameters
  • Optional: automatic MFCs
Gas flows: Air
  • 585-3600 slph (15L)
  • 1170-7200 slph (30L)
Gas flows: Air
  • -
Gas flows: N2
  • -
Gas flows: N2
  • -
Gas flows: N2
  • -
Gas flows: N2
  • -
Gas flows: O2
  • 117-900 slph (15L)
  • 234-1800 slph (30L)
Gas flows: O2
  • -
Gas inlet to vessel
  • Standard: Sparger
  • Optional: Overlay
Gas inlet to vessel
  • Sparger and Overlay
Gas lines
  • Standard: Air
  • Optional: conversion of existing gas or addition of extra gas lines
Gas lines
  • Standard: Air, O2, N2 and CO2
dosage module
dosage module
Local on/off pump control button
  • -
Local on/off pump control button
  • -
Pumps
  • Standard: 3x fixed speed
  • Optional: extra variable speed pumps
Pumps
  • Standard: 3x fixed speed
  • Optional: extra variable speed pumps
temperature control
temperature control
Cooling
  • Secondary circuit from an external chilled water source to heat exchanger in main circuit
Cooling
  • Secondary circuit from an external chilled water source to heat exchanger in main circuit
Heating
  • Electrical resistance in water circuit
Heating
  • Electrical resistance in water circuit
instrumentation
instrumentation
Basic instrumentation package
  • pH, DO, temperature, level
Basic instrumentation package
  • pH, DO, temperature, level
expansion possibilities
expansion possibilities
Additional sensors (and associated control loops)
  • Optional
Additional sensors (and associated control loops)
  • Optional
Advanced Gas Module
  • Optional
Advanced Gas Module
  • Included by default
Continuous process module
  • Optional
Continuous process module
  • Optional
Other customized modules
  • Optional
Other customized modules
  • Optional
Perfusion module
  • Optional
Perfusion module
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Variable speed pump
  • Optional
Variable speed pump
  • Optional
available mechanical accessories
available mechanical accessories
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Several types of Turbines
  • Additional Port Plugs
  • Sterile Access Ports
  • Crane
  • Stairs
  • Spray ball
  • Sight Glass and Light
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Several types of Turbines
  • Additional Port Plugs
  • Sterile Access Ports
  • Crane
  • Stairs
  • Spray ball
  • Sight Glass and Light
gmp
gmp
Available
  • Optional
Available
  • Optional
software
software
HMI
  • Integrated touch panel PC
HMI
  • Integrated touch panel PC
Installed SW
  • MARTA
Installed SW
  • MARTA
Remote access
  • -
Remote access
  • -
utility requirements
utility requirements
Chilled water
  • -
Chilled water
  • -
Compressed air
  • -
Compressed air
  • -
Electricity
  • -
Electricity
  • -
Steam
  • -
Steam
  • -

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