Stirred Microbial Fermenters

Microbial fermentation refers to the process by which different substrates are converted by a variety of microorganisms under anaerobic or aerobic conditions to desired products, for the the pharma, industrial, food or agricultural spaces.
These processes are carried out by a vast group of microorganisms, including bacteria, yeast and microalgae among others. Although these are very diverse in their physiology and metabolism, they all share some needs that can be solved by a common bioreactor technology. Moreover, special needs for each strain and application can be solved by the vast number of additional functional modules and PATs that Bionet's bioreactors are able to integrate.

What are the common characteristics that microbial bioreactors share in its core design:

Microbiology vessel

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The high demand for oxygen by many microorganisms is the cause of the long geometry of the bioreactor vessels. With a vessel aspect ratio (H:D) close between 1.6:1 and 2:1 at the working volume, this gives the gas bubbles a longer residence time in the liquid to enhance the oxygen transfer

This is maintained across the entire Bionet’s laboratory, pilot and industrial bioreactors, which improves the performance of scale-up activities.

f0/f1 bioreactor vessel
Stirred Microbial Fermenter
f2 bioreactor vessel
Industrial bioreactor Stirred Microbial Fermenter
f3/fs bioreactor vessel

Microbial processes’
relevant parameters

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In microbiology applications the bioreactor conditions that commonly have an impact on the strain’s metabolic pathway undertaken, the productivity and the product quality are pH, dissolved oxygen (DO), temperature and foam generation.

Bionet’s microbial bioreactors include the instrumentation and actuators required for the measurement and control of these parameters by default.

Moreover, these models allow for an expansion of its functionalities via the integration of optional instrumentation and actuators to the BCU (Bioreactor Control Unit) in a Plug&Play manner.

PATs package
  • Dissolved Oxygen (DO)
  • pH
  • Temperature
  • Foam presence / Level
Actuators package:
  • Agitation(0-2000 rpm; Rushton impellers)
  • 3 peristaltic pumps (acid, base and antifoam)
  • 2 gas lines (for O2 and air by default)
  • Water circuit

bioprocess
software

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The Microbial Bioreactors can work with ROSITA or MARTA, depending on the bioreactor model.

Both Softwares relate the information from the sensors and the actuators functioning to allow for the following features:

  • Real-time visualization
  • Automation
  • Data registration
  • Remote control

What additional functionalities can be of interest in
microbial appications, and what technologies
does Bionet provide for these?

  • bBreath
    The Plug&Play module you need to carry out O2/CO2 composition analysis of your bioreactor exhaust gas (i.e. metabolic predictions) and get the maximum of this data to enhance the quality and productivity of your process.
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  • bVSP
    The Variable Speed Pump is the Plug&Play module you need to carry out substrate additions (i.e. for Fed-batch and semi-continuous processes) or withdrawal/harvesting actions according to a number of feeding/bleeding profiles.
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  • bCPM
    The Plug&Play module you need to carry out different continuous strategies for an increase in your bioprocess productivity.
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  • Flexible Gas Module
    This is the software module you need to be able to select other gas than air and O2, required for anaerobic processes or to use CO2 as an acidifying agent for pH control.
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  • bScale
    The bScale is the Plug&Play module that you need for the connection of scales, from a range of scale precisions and brands used in lab and production settings.
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  • Other Add-Ons
    The Plug&Play module you need to carry out O2/CO2 composition analysis of your bioreactor exhaust gas (i.e. metabolic predictions) and get the maximum of this data to enhance the quality and productivity.
  • Upstream Services
    We reduce the "time-to-market" of new bioproducts thanks to our expertise to provide a holistic bioprocess solution. We do this by accompanying our equipment with a range of process services that help clientes to take crucial decisions and support them all the way through the selection and operation of the technologies, and the acquisition of the scientific knowledge necessary to enhance the potential of the process. This includes Upstream Proof-of-Concept Trials, Upstream Optimization Services, Bioprocess Scale-Up, Installation and training and Fermentation Courses.
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Microbial Bioreactor Models

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