Downstream Bioprocessing

M1 Tangential Flow Filtration System

Benchtop unit for micro and ultra filtration of biomolecules with ceramic and hollow fibe

Your flexible tangential flow filtration (TFF) system for the concentration/clarification of your bioprocess’s biomolecules and biomass at lab and pilot use and in small production.

IT’S TIME TO PLAN YOUR DOWNSTREAM!

The M1 TFF unit is a unique solution for all those seeking a compact system for concentration/purification of biomolecules and biomass from fermentation or cell culturing broths at lab scale through TFF and/or for those wanting to evaluate the TFF potential on their processes.

Whether your product of interest is a vaccine, an enzyme, a monoclonal antibody or a recombinant protein (among others), TFF could be the most suitable technology for the downstream of your process. It is very important you start testing your process performance as soon as you have a feedstock to try on.

The M1 allows for a deep study of the impact of all relevant parameters in terms of both the most optimal configuration of the equipment and the operation itself, crucial in the R&D and optimization stages. Experiments at this stage include:

  • Election of the optimum membrane material and pore size.
  • Generation of filtrate flux and transmembrane pressure (TMP) curves at different feed circulation flow rates, in order to elucidate the most optional operating conditions (i.e. flow rate, TMP and filtrate flux).
  • Calculation of the achievable concentration factor.
  • Election of the most optimal temperatures to work at.

Moreover, in production stages it allows for a tight control of all operative parameters.

THE FLEXIBILITY YOUR DOWNSTREAM NEEDS

The M1 provides an enormous flexibility in the form of the range of options regarding the type of membrane technologies that can be used:

  • Two types of membranes, ceramic and hollow fiber, and from a range of leading vendors (GE Healthcare, TAMI, SPECTRUM Labs, etc) can be interchangeably integrated in the same equipment.
  • These membranes are available in a number of configurations:
    • 21 different pore sizes in the microfiltration, ultrafiltration and spaces (from 1.4 µm in the microfiltration space to less than 1kDa in the ultrafiltration space).
    • Different number of channels (in ceramic) and thereby membrane surface area available.

This flexibility makes it a unique solution for those with a range of bioprocesses at their hand as well as for those evaluating the scale-up of their bioprocesses and the potential of the TFF as their downstream solution.

ENSURING YOUR BIOMASS AND BIOMOLECULES QUALITY

The system provides the robustness, precision and delicacy that your bioprocess and the resulting biomass and/or biomolecules require via different mechanisms and components:

  • An exquisite pumping technology that allows the application of a big range of flow rates and transmembrane pressures and flow rates.
  • An excellent temperature control through the jacketed stainless steel tank allows to work with very low temperature to ensure the stability of the product.
  • A wise process design that generates a very small dead volume, leading to the achievement of high concentration factors (CF).

AUTOMATION AS A FRIEND

You can guide the M1 system to operate manually or the M1 will take care of this automatically, pooling powerful tools for a tight control over operative parameters at preset values (e.g. for Transmembrane Pressure, Permeate Pressure), and with ways to calculate, register and manage the data.

TECHNICAL SPECIFICATIONS

MODEL M1

commercial claims and positioning
commercial claims and positioning
Applications
  • Microfiltration, Ultrafiltration
Brief description
  • Ideal for concentration/purification of biomolecules (in the food, agriculture, industrial biotech, and biopharma sectors) of small volumes at R&D scale and development, optimization and scale-up activities
dimensions
dimensions
Operation footprint (h x w x l)
  • 540 x 650 x 600 mm
vessel and volumes
vessel and volumes
Concentration factor
  • -
Dead volume (ml)
  • 300
Jacketed
  • Included by default
Recomended batch volume
  • -
Vessels working volume
  • 4.5 L
membranes spiral wound
membranes spiral wound
Effective length
  • -
Pore size
  • -
Pressure
  • -
Surface area
  • -
Temperature
  • -
membranes hollow fiber
membranes hollow fiber
Effective length
  • 20 cm
Pore size
  • 0.05-0.65 μm (MF)
  • 1-750 kDa (UF)
Pressure
  • 50º
Surface area
  • 0.047-0.1 m2
Temperature
  • 2 barg
membranes ceramic
membranes ceramic
Effective length
  • 20 cm
Pore size
  • 0.1-1.4 μm (MF)
  • 1(UUF)-10-750 kDa
Pressure
  • 80º
Surface area
  • 0.0047-0.0132 m2
Temperature
  • 0.5-2 barg (MF)
  • 0.5-5 barg (UF)
recirculation pump
recirculation pump
Motor
  • 750W, 2200 rpm (at 50Hz)
agitation
agitation
Agitator
  • -
Speed (rpm)
  • -
Turbines
  • Optional
temperature actuators
temperature actuators
Cooling
  • Opening of valves for renewal of direct chilled water supply from external chiller to jacket water circuit
Heating
  • Electrical resistance within water circuit
instrumentation
instrumentation
Conductivity
  • Optional
Feed flow indicator
  • -
Level transmitter
  • -
Load cell/Permeate scale
  • Optional
Permeate flow indicator
  • -
Pressure indicator at membrane module entry
  • Included by default
Pressure indicator at membrane module exit (retentate return)
  • Included by default
Pressure indicator at permeate return
  • -
Pressure transducers (to allow automation and alarms)
  • Optional
Tank temperature
  • Included by default
ph
  • Optional
process parameters general
process parameters general
Fluid Pressure
  • 6 barg (ceramic)
  • 2 barg (hollow fiber)
Minimum working volume
  • 100-200 ml
Sterilization
  • -
Temperature
  • 80º (ceramic)
  • 50º (hollow fiber)
process parameters manual
process parameters manual
Feed flow rate (rpm)
  • Included by default (via pump frequency variator)
Process finalization
  • Included by default (via manual stoppage of pump)
TMP
  • Included by default (via back-pressure valve)
process parameters automatic
process parameters automatic
Permeate Back Pressure
  • Optional (via Back Pressure Valve)
Safety pressure
  • -
TMP
  • Optional (via Back Pressure Valve)
Temperature (via automatic valves)
  • Optional
process parameters calculations
process parameters calculations
Concentration Factor
  • -
Filtration flux rate
  • -
Shear rate
  • -
TMP
  • -
Volumetric Throughput
  • -

Start typing and press Enter to search

Like any other website, we use our own and third-party cookies so that everything works correctly, by continuing with your visit you accept the use of cookies for statistical purposes. More info

Los ajustes de cookies de esta web están configurados para "permitir cookies" y así ofrecerte la mejor experiencia de navegación posible. Si sigues utilizando esta web sin cambiar tus ajustes de cookies o haces clic en "Aceptar" estarás dando tu consentimiento a esto.

Cerrar