M1 Labscale Tangential Flow Filtration System

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[mk_padding_divider size=»70″][mk_fancy_title tag_name=»h3″ size=»40″ txt_transform=»uppercase» margin_bottom=»0″ font_family=»none» align=»center» el_class=»scada»]IT’S TIME TO DEVELOP YOUR DOWNSTREAM AND CHOOSE A SUITABLE LABSCALE TFF SYSTEM![/mk_fancy_title]

Don’t hesitate in jumping ahead and testing Tangential (Cross) Flow Filtration (TFF) for your bioprocess downstream. TFF could well be the most suitable technology for this, and it is very important you start testing your process performance as soon as you have a feedstock to try on.

The M1 unit is a unique solution for all those seeking a compact system for concentration and/or clarification of the biomass and/or biomolecules from their microbial fermentation/culturing processes at lab scale.

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WHY IS M1 AN UNIQUE LABSCALE SYSTEM FOR TECHNOLOGY SCREENING, OPTIMIZATION AND SCALE-UP ACTIVITIES?

There are a number of product characteristics and technology configurations that have an impact in the potential of TFF to your process and its scalability to larger scales.

The M1 offers the flexibility (in the form of modularity and membrane selection) required for creating the right configuration for your filtration system.

Moreover, it provides you with the right technological components (e.g. recirculation pump) and process flow for your process scalability. Meaning you can be confident that your results can be transferred to a production scale.

Finally, the combination of a IOT-based architecture and our ROSITA software solutions renders your process consistent and reproducible, and provides the data for a complete test analysis.

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M1 is the right tool for:

  • Technology selection (membrane technology and materials).
  • Selection of optimum pore size.
  • Calculation of achievable concentration factor.
  • Generation of filtrability curves.
  • Cleaning procedures.
  • Evaluation of the impact of the operative parameters (e.g. cross-flow velocity, pressyre and temperature) regarding yields, flows an dproduct quality.
  • Small productions.
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[mk_fancy_title tag_name=»h3″ size=»45″ txt_transform=»uppercase» margin_bottom=»0″ font_family=»none»]THE FLEXIBILITY YOUR DOWNSTREAM NEEDS[/mk_fancy_title]

The M1 allows you to select the most optimum membrane technology and use a complete range of pore sizes, surface areas and channel sizes, so that you find the right solution; without the limitations of membrane vendor systems. This ramge of options, briefly stated here, provides an enourmous flexibility.

    • Three types of membranes, Cassettes, Ceramic and Hollow Fibre, from main leading vendors, which can be interchangeably integrated and tested in the M1. This allows for un-parallel capabilities for comparing membranes using identical process conditions and data registration for analysis.
    • These membranes are available, in tirn, in a number of configurations:
    • 21 different pore sizes in the microfiltration, ultrafiltration and spaces (from 1.4 µm in the microfiltration space to less than 1kDa in the ultrafiltration space).
    • Different number of channels (in ceramic) and thereby membrane surface area available.
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[mk_fancy_title tag_name=»h3″ size=»45″ txt_transform=»uppercase» margin_bottom=»0″ font_family=»none»]THE SCALABILITY FOR YOUR PROCESS FUTURE[/mk_fancy_title]

bFlow: a Smart feeding pump

The bFlow is the smart pump used as a feeding pump in the M1. It is the core of our M1 series and part of our Bionet bSmart family of lab process modules. It is an exceptional pump with capabilities beyond standard lab pumps.

What makes it so exceptional?

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  • A unique range of flows and pressure. From 800 to 10,000 ml per minute and from 0 to 6 barg working pressure. All driven by a servomotor for precise control of rpms.
  • The right pump technology. The multilobe pump technology guarantees your lab results are truly valid for scale-up and provides extraordinary gentleness for sensible biomass and biomolecules.
  • Connected and smart. The bFlow comes with ready connections to multiple sensors and data logging for batch data recording for a later analysis. Beyond that you can automate some process parameters.
  • Double interface. You can control the pump through a physical control panel with buttons and display or through a web interface through a wireless connection with ROSITA SW.
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[mk_fancy_title tag_name=»h3″ size=»45″ txt_transform=»uppercase» margin_bottom=»0″ font_family=»none»]AUTOMATION AS A FRIEND[/mk_fancy_title]

The M1 is a manual unit with some automatic controls and full data registration of system and process parameters.

This data come from actuators or instruments as well as a result of calculations which can be made based on the registered data and that allows for further data logging and additional control strategies.

    • Cross flow rate. Or recirculation rate or retentate flow can be monitored and controlled with the addition of a Flowmeter (Optional) with a control loop with the pump driver.
    • Filterability. Permeate flux (in l/h) can be monitored with a connected scale (Optional).
    • Product temperature. With a TT on the vessel.
    • Pressure. Pressure is measured in 2 points as standard (feed and permeate) and one optional (permeate) allowing for calculation of Transmembrane Pressure and other critical process parameters.
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[mk_fancy_title tag_name=»h3″ size=»45″ txt_transform=»uppercase» margin_bottom=»0″ font_family=»none»]SUPPORT AS THE CORE OF OUR STRATEGY[/mk_fancy_title]

With the aim to reduce our clients’ upfront technology investment at early phases and/or to help them obtain the highest productivity with their processes, all our technologies are accompanied by advanced packages of Process Services.

At the stages of evaluating TFF as a potentially suitable Downstream technology for your process, and of selecting the right TFF system configuration for your process, here you have a link to the Downstream Process Services that could become relevant:

    • Downstream Technology Screening
    • Downstream Proof-of-Concept Trials
    • Downstream Optimization Services
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[mk_fancy_title tag_name=»h3″ size=»30″ txt_transform=»uppercase» margin_bottom=»0″ font_family=»none»]M1 TECHNICAL SPECIFICATIONS[/mk_fancy_title]
[tec_tab titulo=»APPLICATION DETAILS» abierto=»true» subtitulo1=»Applications» contenido1=»Microfiltration, Ultrafiltration » subtitulo2=»Batch volume» contenido2=»Up to 20L (assuming a good filtrability)»][tec_tab titulo=»DESIGN DETAILS» abierto=»true» subtitulo1=»Operation footprint (H x W x D)» contenido1=»540 x 650 x 600 mm» subtitulo2=»Vessel working volume » contenido2=»3 L (other volumes available)» subtitulo3=»Vessel type» contenido3=»Single wall (jacketed vessel available)» subtitulo4=»Vessel material» contenido4=»Borosilicate Glass» subtitulo5=»Dead volume (ml)» contenido5=»200 «][tec_tab titulo=»MEMBRANES» subtitulo1=»Membrane vendor» contenido1=»Neutral » subtitulo2=»Membrane type» contenido2=»Reusable and single-use» subtitulo3=»Membrane types» contenido3=»Ceramic, Hollow Fiber and Cassettes»][tec_tab titulo=»MEMBRANES Pore Size (for MF)» subtitulo1=»Ceramic (micrometers)» contenido1=»0.05, 0.1, 0.14, 0.2, 0.4, 0.45, 0.5, 0.8, 1.2, 1.4″ subtitulo2=»Hollow Fiber (micrometers)» contenido2=»0.1, 0.2, 0.45, 0.65″ subtitulo3=»Cassette (micrometers)» contenido3=»0.1, 0.2, 0.45, 0.65″][tec_tab titulo=»MEMBRANES Pore Size (for UF)» subtitulo1=»Ceramic » contenido1=»1, 5, 10, 20, 50, 100, 150, 300 kD
20, 50 nm» subtitulo2=»Hollow Fiber» contenido2=»1, 3, 5, 10, 30, 50, 70, 100, 300, 500, 750 kD» subtitulo3=»Cassette » contenido3=»1, 3, 5, 8, 10, 30, 50, 70, 100, 200, 300, 500, 1000 kD»][tec_tab titulo=»MEMBRANES Surface área» subtitulo1=»Ceramic » contenido1=»up to 0,01 m2″ subtitulo2=»Hollow Fiber» contenido2=»up to 0,079 m2″ subtitulo3=»Cassette » contenido3=»up to 0,5 m2″][tec_tab titulo=»bFlow (recirculation pump)» subtitulo1=»Material» contenido1=»SS 316L Rotor and casing, EPDM Elastomers» subtitulo2=»Surface finishes» contenido2=»Inner surfaces finished to Ra 0.6μm» subtitulo3=»Motor» contenido3=»Servo-motor drive for maximized flow range with Integrated servo controller» subtitulo4=»Operation details» contenido4=»Fully drainable CIP compatible design» subtitulo5=»Flow range» contenido5=»0.8-10 L/min» subtitulo6=»Pressure range» contenido6=»0 – 6 barg»][select_tab titulo=»PROCESS CONTROL» abierto=»true»]

PROCESS CONTROL Manual/Non-feedback Automated Feedback Automated (a.k.a control loop) Data log Description
bFlow speed (rpm) Basic: configurable pump “rpm” and pump data log Optional: feedback-automatic control and flow data log )if recirculation flow meter is installed)
Recirculation flow Basic: configurable pump “rpm” and pump data log Optional: feedback-automatic control and flow data log )if recirculation flow meter is installed)
TMP (Transmembrane Pressure) Basic: manual control of retentate manual valve Optional: calculation and data log (if permeate pressure is installed)
Permeate pressure Optional: indirect manual control (if manual valve is installed); data log (if permeate sensor is installed)
Feed Pressure Basic: indirect control; data log (since sensor is installed)
Retentate Pressure Basic: manual control (since retentate manual valve is included); and data log (since sensor is installed)
Permeate Flow Optional: manual control (if manual valve is installed); data log (if scale is installed)
Product temperature Basic: data log (since TT is included)

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