Upstream Bioprocesing

F3 Bioreactor

Stainless steel Steam in Place (SIP) pilot and industrial scale bioreactors

Bionet F3 models is a unique concept for those seeking for premium quality a Steam In Place (SIP) Bioreactor of industrial scale and conception, with the quality of a standardized product but with the flexibility to develop and scale-up new bioprocesses.

A system with a state-of-the-art technology core technology and many details, has been created to be the market reference in pilot or small industrial fermentation and cell culture. It comes in 3 models with 50, 100 and 200 l maximum working volume.

If what you need is a fully customized bioreactor, beyond the standard features, or bigger volumes than 200 l . See more…

POWERFUL AND EXPANDABLE

The F3 are meant to be the cornerstone of your industrial production and advanced pilot activities. For that it integrates proven industrial technology solutions

Agitation

Bottom agitation system, with a servo gives a complete (from almost zero to hundreds of rpms) broad speed range and power input, adapted to the needs of your culture. Being bottom placed allows for clean and light top lid, giving you easier maintenance and numerous ports. Available with standard impellers (Rushton, marine, pitch blade) or special designs on demand. Mechanical seal can be single, double (SIP) or magnetic coupling.

Gassing

The F3 has the needed add-ons for giving you the technology for the most demanding gas control. With our Advanced Gas Module for Cell Culture (with Air, N2, O2 and CO2, and inlets in sparger and doom) you will be able to the control the parameters you need for optimizing and qualify your protein production.

Temperature control

The temperature control system includes a jacket which covers practically the whole vessel, combined with a primary circuit with heater, heat exchanger for cooling water and recirculation pump. All this provides accurate temperature control and big heat exchange capabilities; even for the most demanding cultures.

Integrated CIP

As its smaller sister the F2 the F3 can integrate a CIP system. All in the same frame, with no extra-footprint, using the dossing pumps for acid and base and the pH probe, the CIP can be made without external intervention. All controlled from our control SW MARTA in which the CIP Module allows for programming of recipes. which can be created and saved to allow for standardization of cleaning and productivity.

ADVANCED INSTRUMENTATION
AND CONTROL

Providing the possibility to integrate a complete range of instrumentation and actuators, and allowing all kinds of associated control strategies helps you to better understand, improve and control your processes.

Example of instruments which can be added beyond the standard configuration are: Pressure, Optical Density, Viable Cells, Dissolved CO2, Exhaust gas composition, Redox, Weight for reactor and additions and many others.

Most of these instruments have a corresponding MARTA SW module. These specific SW modules allows the user to select parameter as part of your control strategies and gives additional calculated information (e.g. OTR or OUR) in real time.

Gmp designed,
built & qualified

As all BIONET bioreactors and filtration units, the F3 can be built and qualified under GMP guidelines to allow the validation of your processes in a regulated environment.

Our GMP approach is structured so it can be adapted to your specific project and regulatory needs. The upgrade from a standard unit to a GMP one will affect many issues on the design and construction: Technologies, Calibrations, Documentation, Qualification and SW (including ERs under CFR 21 c 11).

At the F3 series we have structured these GMP features in preconfigured technology and service packages, so they can be easy implemented and adapted to your specific demands, saving time and money.

DQ, IQ & OQ

MARTA CONTROL SOFTWARE

MARTA is the Automation SW which comes installed in the F3 units. In this model has off-the-shelve solutions for Cell Culture, Fermentation which can be expanded with additional modules for local CIP, new instrumentation or advanced gassing or dosing control.

TECHNICAL SPECIFICATIONS

MODEL F3 MB

MODEL F3 CC

general
general
AUTOCLAVE DIMENSIONS (W X H X D)
  • NA
AUTOCLAVE DIMENSIONS (W X H X D)
  • NA
MATERIAL
  • 316L SS in surfaces in contact with product
  • 304 SS in frame
MATERIAL
  • 316L SS in surfaces in contact with product
  • 304 SS in frame
MULTIBIOREACTOR
  • NA
MULTIBIOREACTOR
  • NA
TOTAL FOOTPRINT ON BENCH (W X H X D)
  • 1200 x 1993 x 740
TOTAL FOOTPRINT ON BENCH (W X H X D)
  • 1200 x 1993 x 740
vessel
vessel
Minimum Working Volume (L)
  • 6 (15L)
  • 12 (30L)
Minimum Working Volume (L)
  • 7 (15L)
  • 10.5 (30L)
Wall
  • Jacketed
Wall
  • Jacketed
Working volumes available
  • 50, 100, 200 L
Working volumes available
  • 15, 30
agitation
agitation
Agitator
  • Top mounted
  • Standard: Single mechanical seal
  • Optional: double mechanical seal
Agitator
  • Top mounted
  • Standard: Single mechanical seal
  • Optional: double mechanical seal
Impellers
  • Optional: Marine/Pitched blade; or customised
  • Standard: 3x Rushton
Impellers
  • Standard: 1x Marine
  • Optional: customised (upon demand)
Motorpower
  • 0.6 kW (15L)
  • 1.1 kW (30L)
Motorpower
  • 0.37 kW (15L)
  • 0.6 kW (30L)
Speed (rpm)
  • 10-400
Speed (rpm)
  • 10-400
gassing module
gassing module
0.22 µm filter in gas lines
  • Included by default
0.22 µm filter in gas lines
  • Included by default
Condenser
  • Optional
Condenser
  • Optional
Filter at exhaust gas
  • Optional
Filter at exhaust gas
  • Optional
Gas flow control and gas mixture
  • Standard: manual via rotameters
  • Optional: automatic MFCs
Gas flow control and gas mixture
  • Standard: manual via rotameters
  • Optional: automatic MFCs
Gas flows: Air
  • 585-3600 slph (15L)
  • 1170-7200 slph (30L)
Gas flows: Air
  • -
Gas flows: N2
  • -
Gas flows: N2
  • -
Gas flows: N2
  • -
Gas flows: N2
  • -
Gas flows: O2
  • 117-900 slph (15L)
  • 234-1800 slph (30L)
Gas flows: O2
  • -
Gas inlet to vessel
  • Standard: Sparger
  • Optional: Overlay
Gas inlet to vessel
  • Sparger and Overlay
Gas lines
  • Standard: Air
  • Optional: conversion of existing gas or addition of extra gas lines
Gas lines
  • Standard: Air, O2, N2 and CO2
dosage module
dosage module
Local on/off pump control button
  • -
Local on/off pump control button
  • -
Pumps
  • Standard: 3x fixed speed
  • Optional: extra variable speed pumps
Pumps
  • Standard: 3x fixed speed
  • Optional: extra variable speed pumps
temperature control
temperature control
Cooling
  • Secondary circuit from an external chilled water source to heat exchanger in main circuit
Cooling
  • Secondary circuit from an external chilled water source to heat exchanger in main circuit
Heating
  • Electrical resistance in water circuit
Heating
  • Electrical resistance in water circuit
instrumentation
instrumentation
Basic instrumentation package
  • pH, DO, temperature, level
Basic instrumentation package
  • pH, DO, temperature, level
expansion possibilities
expansion possibilities
Additional sensors (and associated control loops)
  • Optional
Additional sensors (and associated control loops)
  • Optional
Advanced Gas Module
  • Optional
Advanced Gas Module
  • Included by default
Continuous process module
  • Optional
Continuous process module
  • Optional
Other customized modules
  • Optional
Other customized modules
  • Optional
Perfusion module
  • Optional
Perfusion module
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Variable speed pump
  • Optional
Variable speed pump
  • Optional
available mechanical accessories
available mechanical accessories
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Several types of Turbines
  • Additional Port Plugs
  • Sterile Access Ports
  • Crane
  • Stairs
  • Spray ball
  • Sight Glass and Light
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Several types of Turbines
  • Additional Port Plugs
  • Sterile Access Ports
  • Crane
  • Stairs
  • Spray ball
  • Sight Glass and Light
gmp
gmp
Available
  • Optional
Available
  • Optional
software
software
HMI
  • Integrated touch panel PC
HMI
  • Integrated touch panel PC
Installed SW
  • MARTA
Installed SW
  • MARTA
Remote access
  • -
Remote access
  • -
utility requirements
utility requirements
Chilled water
  • -
Chilled water
  • -
Compressed air
  • -
Compressed air
  • -
Electricity
  • -
Electricity
  • -
Steam
  • -
Steam
  • -

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