Upstream Bioprocesing

F1 Bioreactor

Benchtop autoclavable advanced bioreactor for R&D, optimization and biomolecules productions

The F1 series include autoclavable bench scale bioreactors/fermenters designed to meet the challenging and widely diverse R&D requirements and small-scale biomolecules production by using microbial and animal cells for biopharmaceutical-, food-, agricultural- and other biotechnological applications.

Learn

Interchangeable jacketed vessels of 1, 3, 5, 8 and 10 liters

The F1 bioreactor models combine the highest technological standards of the sector with premium quality and a reduced investment.
Though a serially produced and standardized to combine the highest technological solutions for the common market demands, it is well thought for its expansion and customization towards a range of special requirements. This is possible thanks to:

A CONFIGURABLE DESIGN

A modular design, that allows for the expansion of hardware and software capabilities in the form of advanced modules that follow the plug and play concept.

ADVANCED GAS STRATEGY

An Advanced Gas Strategy, for automatic mixing of up to 4 gases and their inlet via both sparger and overlay. The plugging of this module will enable software capabilities such as the acidification of the broth (i.e. pH control) via acid or CO2, and the use of N2 as an actuator in the DO cascade.

Air, O2, CO2, N2

Sparger/Overlay

CONTINUOUS PROCCESS MODULE

The continuous process module, for the extraction and renewal of media, and the perfusion module for extraction, renewal and separation of biomass from smaller molecular components.

Reversible direction

Pump speeds

4–200rpm

VARIABLE SPEED PUMP

The variable speed pump module, for addition of nutrient in fed-batch processes, which enable further control capabilities in the software such as the addition of nutrient according to growth profiles, and the use of the pump in the cascade control mode of DO.

Reversible direction

Pump speeds

4, 30, 100 rpm

ENHANCING KNOWLEDGE

The availability of spare electronics and software flexibility for the integration of a variety of additional instrumentation (e.g. optical density sensors, gas analyzers, glucose presence sensors) and the integration of their measurements into advanced control strategies.

Integration of a range of process analytical technologies such as optical density sensors, dissolved CO2 probes, Redox sensor, etc., and visualization and use of measurements in advanced bioprocess control loops

Fully equipped

A modular design, that allows for the expansion of hardware and software capabilities in the form of advanced modules that follow the plug and play concept.

FULLY COMPLIANT

F1 offers the possibility to upgrade the equipment to GMP standards at the hardware- (i.e. mechanically), software- and documentation levels.

Bioreactor designed to meet GMP regulatory requirements
Interchangeable jacketed vessels for multibioreactor

DOUBLE YOUR BIOPROCESS

The possibility to perform parallel bioprocessing (with the TWIN version of the equipment).

rosita

Its inseparable friend is ROSITA , Bionet’s proprietary automation software for laboratory use, which allows for a sophisticated and tight automatic control over the processes and provides the user with ways to visualize, analyse and manage the data.

Automation, control, real-time visualization and data registration of bioprocessing data

TECHNICAL SPECIFICATIONS

MODEL F1 MB

MODEL F1 CC

general
general
AUTOCLAVE DIMENSIONS (W X H X D)
  • 220 x 459 (527 with condenser) x 212 (1L, 3L)
  • 276 x 595 (663 with condenser) x 257 (5L & 8L)
  • 286 x 650 x (718 with condenser) x 277 (10L)
AUTOCLAVE DIMENSIONS (W X H X D)
  • 220 x 459 (527 with condenser) x 212 (2L)
  • 276 x 595 (663 with condenser) x 257 (5L & 8L)
  • 286 x 650 x (718 with condenser) x 277 (10L)
MATERIAL
  • Vessel: Borosilicate glass
  • Other surfaces in contact with product: AISI 316L and EPDM
MATERIAL
  • Vessel: Borosilicate glass
  • Other surfaces in contact with product: AISI 316L and EPDM
MULTIBIOREACTOR
  • Two vessels per BCU and software
MULTIBIOREACTOR
  • Two vessels per BCU and software
TOTAL FOOTPRINT ON BENCH (W X H X D)
  • 895-995 x 840 x 500 (SINGLE)
  • 1120-1330 x 840 x 610 (TWIN)
TOTAL FOOTPRINT ON BENCH (W X H X D)
  • 895-995 x 840 x 500 (SINGLE)
  • 1120-1330 x 840 x 610 (TWIN)
vessel
vessel
Minimum Working Volume (L)
  • 0.7 (1L)
  • 1.4 (3L)
  • 3.0 (5L)
  • 3.9 (8L)
  • 5.5 (10L)
Minimum Working Volume (L)
  • 1.6 (2L)
  • 3.6 (5L)
Wall
  • Jacketed
Wall
  • Jacketed
Working volumes available
  • 1, 3, 5, 8, 10
Working volumes available
  • 2,5
agitation
agitation
Agitator
  • Top mounted
  • Single mechanical seal
  • *Optional: double mechanical seal
Agitator
  • Top mounted
  • Single mechanical seal
  • *Optional: double mechanical seal
Impellers
  • Optional: Marine/Pitched blade; or customised
  • Standard: 2x or 3x Rushton
Impellers
  • Standard: 1x Marine
  • Optional: customised (upon demand)
Motorpower
  • 0.37 kW
Motorpower
  • 0.37 kW
Speed (rpm)
  • 0-2000
Speed (rpm)
  • 0-500
gassing module
gassing module
0.22 µm filter in gas lines
  • Included by default
0.22 µm filter in gas lines
  • Included by default
Condenser
  • Optional
Condenser
  • Optional
Filter at exhaust gas
  • Included by default
Filter at exhaust gas
  • Included by default
Gas flow control and gas mixture
  • Automatic via MFCs
Gas flow control and gas mixture
  • Automatic via MFCs
Gas flows: Air
  • 0.2-18 slpm
Gas flows: Air
  • 0-750 sscm
Gas flows: N2
  • 0.1-9 slpm
Gas flows: N2
  • 0-750 sscm
Gas flows: N2
  • 0.1-9 slpm
Gas flows: N2
  • 0-750 sscm
Gas flows: O2
  • 0.1-9 slpm
Gas flows: O2
  • 0-750 sscm
Gas inlet to vessel
  • Standard: Sparger
  • Optional: Overlay
Gas inlet to vessel
  • Sparger and Overlay
Gas lines
  • Standard: Air and O2
  • Optional: conversion of existing gas or addition of Advanced Gas Module
Gas lines
  • Standard: Air, O2, N2 and CO2
dosage module
dosage module
Local on/off pump control button
  • -
Local on/off pump control button
  • -
Pumps
  • Standard: 3x fixed speed
  • Optional: Variable Speed Pump module or Continuous Processing Module (up to 3 pumps)
Pumps
  • Standard: 3x fixed speed
  • Optional: Variable Speed Pump module or Continuous Processing Module (up to 3 pumps)
temperature control
temperature control
Cooling
  • Circuit from an external chilled water source (not included) to jacket
Cooling
  • Circuit from an external chilled water source (not included) to jacket
Heating
  • Heating blanket
Heating
  • Heating blanket
instrumentation
instrumentation
Basic instrumentation package
  • pH, DO, temperature, level
Basic instrumentation package
  • pH, DO, temperature, level
expansion possibilities
expansion possibilities
Additional sensors (and associated control loops)
  • Optional
Additional sensors (and associated control loops)
  • Optional
Advanced Gas Module
  • Optional
Advanced Gas Module
  • Included by default
Continuous process module
  • Optional
Continuous process module
  • Optional
Other customized modules
  • Optional
Other customized modules
  • Optional
Perfusion module
  • Optional
Perfusion module
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Variable speed pump
  • Optional
Variable speed pump
  • Optional
available mechanical accessories
available mechanical accessories
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Additional Port Plugs
  • Range of turbines
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Additional Port Plugs
  • Range of turbines
gmp
gmp
Available
  • Optional
Available
  • Optional
software
software
HMI
  • Integrated touch PC (included), connected via Ethernet
HMI
  • Integrated touch PC (included), connected via Ethernet
Installed SW
  • ROSITA
Installed SW
  • ROSITA
Remote access
  • Additional Ethernet port, for local remote access from any user within the LAN and external remote access from outside the client’s site via a safe VPN tunnel
Remote access
  • Additional Ethernet port, for local remote access from any user within the LAN and external remote access from outside the client’s site via a safe VPN tunnel
utility requirements
utility requirements
Chilled water
  • Cooling power: 140-1100 W (depending on volume and SINGLE vs. TWIN)
  • Minimum pump pressure: 0.8-1 barg
  • Minimum pump flow: 6 L/min (SINGLE) 12 L/min (TWIN)
Chilled water
  • Cooling power: 140-1100 W (depending on volume and SINGLE vs. TWIN)
  • Minimum pump pressure: 0.8-1 barg
  • Minimum pump flow: 6 L/min (SINGLE) 12 L/min (TWIN)
Compressed air
  • 1-2 vvm at 1.5 barg
Compressed air
  • 1-2 vvm at 1.5 barg
Electricity
  • 1.1 kW (SINGLE)
  • 2.2 kW (TWIN)
Electricity
  • 1.1 kW (SINGLE)
  • 2.2 kW (TWIN)
Steam
  • -
Steam
  • -

Start typing and press Enter to search

Like any other website, we use our own and third-party cookies so that everything works correctly, by continuing with your visit you accept the use of cookies for statistical purposes. More info

Los ajustes de cookies de esta web están configurados para "permitir cookies" y así ofrecerte la mejor experiencia de navegación posible. Si sigues utilizando esta web sin cambiar tus ajustes de cookies o haces clic en "Aceptar" estarás dando tu consentimiento a esto.

Cerrar