Upstream Bioprocesing

F0-BABY Bioreactor

Benchtop autoclavable bioreactor with external modules for a range of bioprocessing needs in R&D

The F0-BABY series comprise optimal entry level autoclavable fermenters/bioreactors for microbial and cell culturing bioprocessing activities in biopharma-, food- and agricultural- sectors, among others. The system provides a cost-effective and user-friendly alternative to the bigger and more complex equipment, being an ideal solution for R&D as well as training and education purposes.

Start

While offering simplicity at all levels, a small footprint and a neat design, it provides technological solutions for a range of common advanced fermentation and culturing needst. How does the F0 accomplish this and contributes to your bioprocess?:

Max. width

500mm

MAX. WEIGHT

50 kg

Max. Height

632mm

MAX. DEPTH

380 mm

A modular design

A modular design, that allows for the expansion of hardware and software capabilities in the form of advanced modules that follow the plug and play concept.

These modules include:

4-gas mix and inlet to bioreactor via sparger and overlay

Avanced gas module

The Advanced Gas Module, for automatic mixing of up to 4 gases and their inlet via both sparger and overlay. The plugging of this module will enable software capabilities such as the acidification of the broth (i.e. pH control) via acid or CO2, and the use of N2 as an actuator in the DO cascade.

Air, O2, CO2, N2

Sparger/Overlay

CONTINUOUS PROCESS MODULE

The continuous process module, for the extraction and renewal of media, and the perfusion module for extraction, renewal and separation of biomass from smaller molecular components.

Reversible direction
Variable speeds:

4 – 200 rpm

Extraction of broth with biomass and metabolites and renewal of new media
Variable speed peristaltic pump for nutrient additions in fed-batch processes

VARIABLE SPEED PUMP

The variable speed pump module, for addition of nutrient in fed-batch processes, which enable further control capabilities in the software such as the addition of nutrient according to growth profiles, and the use of the pump in the cascade control mode of DO.

Reversible direction
Variable speeds:

4/30/100 rpm

SUPPORTING GROWTH

The F0 is designed to share the same space and the same automation software with their fellow ones, increasing your lab capacity.

FACILITATING KNOWLEDGE

The availability of spare electronics and software flexibility for the integration of a variety of in-situ process analytical technologies (e.g. optical density sensors, gas analyzers, glucose sensors) and the integration of their measurements into advanced control strategies.

EASING OPERATION

A range of accessories that allow for flexibility in the operation and ease bioreactor handling, such as height-adjustable dip tubes, easy to clean additions nozzle, and robust, accessible and interchangeable vessel supports, among many others.

The type and number of accessories will vary depending on the application

rosita

Its inseparable friend is ROSITA , Bionet’s proprietary automation software for laboratory use, which allows for a sophisticated and tight automatic control over the processes and provides the user with ways to visualize, analyse and manage the data.

ROSITA bioprocessing software for the automation, control and analysis of your bioprocess

TECHNICAL SPECIFICATIONS

MODEL F0 MB

MODEL F0 CC

general
general
AUTOCLAVE DIMENSIONS (W X H X D)
  • 220 x 459 (527 with condenser) x 212 (1L, 3L)
  • 276 x 595 (663 with condenser) x 257 (5L)
AUTOCLAVE DIMENSIONS (W X H X D)
  • 276 x 595 (663 with condenser) x 257 (5L)
  • 220 x 459 (527 with condenser) x 212 (2L)
MATERIAL
  • Vessel: Borosilicate glass
  • Other surfaces in contact with product: AISI 316L and EPDM
MATERIAL
  • Vessel: Borosilicate glass
  • Other surfaces in contact with product: AISI 316L and EPDM
MULTIBIOREACTOR CONFIGURATION
  • One vessel per BCU
  • Up to 3 vessels per software license
MULTIBIOREACTOR CONFIGURATION
  • One vessel per BCU
  • Up to 3 bioreactors vessels per software license
STERILIZATION
  • Autoclave
STERILIZATION
  • Autoclave
TOTAL FOOTPRINT (W X H X D)
  • Basic: 440mm x 632mm x 380mm
  • With external modules: 500mm x 632mm x 380mm
TOTAL FOOTPRINT (W X H X D)
  • -
vessel
vessel
Design
  • Flat top and elliptical bottom
Design
  • Flat top and elliptical bottom
Geometry H/D
  • 2.6 (1L)
  • 2.3 (3L & 5L)
Geometry H/D
  • 1.8 (2L)
Glass vessel type
  • Single wall
Glass vessel type
  • Single wall
Minimum Working Volume (L)
  • 0.7 (1L)
  • 1.4 (3L)
  • 3.0 (5L)
Minimum Working Volume (L)
  • 0.9 (1L)
  • 1.6 (2L)
  • 3.6 (5L)
Working volumes available
  • 1,3,5
Working volumes available
  • 2,5
agitation
agitation
Agitator
  • Top mounted
  • Single mechanical seal
Agitator
  • Top mounted
  • Single mechanical seal
Impellers
  • Standard: 2x Rushton
  • Optional: Marine/Pitched blade; or customised
Impellers
  • Standard: 1x Marine
  • Optional: customised (upon demand)
Motorpower
  • 0.4 kW
Motorpower
  • 0.4 kW
Speed (rpm)
  • 0-2000
Speed (rpm)
  • 0-500
gassing module
gassing module
0.22 µm filter in gas lines
  • Included by default
0.22 µm filter in gas lines
  • Included by default
Condenser
  • Optional
Condenser
  • Optional
Filter at exhaust gas
  • Included by default
Filter at exhaust gas
  • Included by default
Gas flow control and gas mixture
  • Automatic via MFCs
Gas flow control and gas mixture
  • Automatic via MFCs
Gas flows: Air
  • 0.2-18 slpm
Gas flows: Air
  • 20-750 sscm
Gas flows: CO2
  • 0.1-9 slpm
Gas flows: CO2
  • 20-750 sscm
Gas flows: N2
  • 0.1-9 slpm
Gas flows: N2
  • 20-750 sscm
Gas flows: O2
  • 0.1-9 slpm
Gas flows: O2
  • 20-750 sscm
Gas inlet to vessel
  • Standard: Sparger
  • Optional: Overlay
Gas inlet to vessel
  • Sparger and Overlay
Gas lines
  • Standard: Air and O2 with MFCs
  • Optional: conversion of existing gas or addition of Advanced Gas Module
Gas lines
  • Standard: Advanced Gas Module (Air, O2, N2 and CO2) with MFCs
dosage module
dosage module
Local on/off pump control button
  • Included by default
Local on/off pump control button
  • Included by default
Pumps
  • Standard: 3x fixed speed for Acid, base and Antifoam
  • Optional: Fed-batch Variable Speed Pump module or Continuous Processing Module (up to 3 pumps)
Pumps
  • Standard: 3x fixed speed for Acid, base and Antifoam
  • Optional: Fed-batch Variable Speed Pump module or Continuous Processing Module (up to 3 pumps)
temperature control
temperature control
Cooling
  • Circuit from an external chilled water source (not included) to cooling finger
Cooling
  • Circuit from an external chilled water source (not included) to cooling finger
Heating
  • Heating blanket
Heating
  • Heating blanket
instrumentation
instrumentation
Basic instrumentation package
  • pH, DO, temperature, level
Basic instrumentation package
  • pH, DO, temperature, level
process expansion possibilities
process expansion possibilities
Additional sensors (and associated control loops)
  • Optional
Additional sensors (and associated control loops)
  • Optional
Advanced Gas Module
  • Optional
Advanced Gas Module
  • Included by default
Continuous process module
  • Optional
Continuous process module
  • Optional
Other customized modules
  • -
Other customized modules
  • -
Perfusion module
  • Optional
Perfusion module
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Scales (for precision in additions, sampling, harvesting, continuous processing and perfusion)
  • Optional
Variable speed pump
  • Optional
Variable speed pump
  • Optional
available mechanical accessories
available mechanical accessories
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Several types of Turbines
  • Additional Port Plugs
Available options
  • Condenser
  • Additions kit
  • Sampling kit
  • Range of Dip Tubes
  • Several types of Turbines
  • Additional Port Plugs
gmp
gmp
Available
  • -
Available
  • -
software
software
HMI
  • External touch PC connected via Ethernet. One PC can control up to 3 units
HMI
  • External touch PC connected via Ethernet. One PC can control up to 3 units
Installed SW
  • ROSITA
Installed SW
  • ROSITA
Remote access
  • Local remote access through a direct LAN connection or external remote access through a properly configured VLAN connection
Remote access
  • Local remote access through a direct LAN connection or external remote access through a properly configured VLAN connection
utility requirements
utility requirements
Chilled water
  • Cooling power: 140-400 W (depending on volumen)
  • Minimum pump pressure: 0.6 barg
  • Minimum pump flow: 3 L/min
Chilled water
  • Cooling power: 140-400 W (depending on volumen)
  • Minimum pump pressure: 0.6 barg
  • Minimum pump flow: 3 L/min
Compressed air
  • 2-3 barg
Compressed air
  • 2-3 barg
Electricity
  • 1 kW
Electricity
  • 1 kW
Steam
  • -
Steam
  • -

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