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Continuous Process

 In Expert References
75

The Continuous Process in the context of a bioreactor operation mode is used to prolong the production phase of a culture during its growth in a steady-state (at a constant rate and in constant conditions) to achieve higher biomass and/or metabolites amounts. There are two main process control strategies that can be implemented in Continuous Processing: the chemostat and the turbidostat methods.

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  • Expert References

    Continuous Process

    The Continuous Process in the context of a bioreactor operation mode is used to prolong the production phase of a culture during its growth in a steady-state (at a constant rate and in constant conditions) to achieve higher biomass and/or metabolites amounts. There are two main process control strategies that can be implemented in Continuous Processing: the chemostat and the turbidostat methods.

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  • Expert References

    Chemical cleaning of membranes

    The chemical cleaning of the ceramic and/or hollow fiber membranes after a filtration stage must receive the attention it deserves. Having defined an effective cleaning protocol is just as important as having optimized filtration conditions when dealing with a tangential flow filtration process in your downstream. Moreover, I would dare to say, the latter is even more important. If after filtering we do not clean properly, the permeability of the membranes will go down batch after batch, resulting in changes to the membranes prematurely and thereby increasing the cost. The “permeability” […]

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  • Expert References

    Never give anything for granted when it comes to cultivating mammalian cells!

    It is widely agreed that the most important quality factor of a bioreactor is its capacity to keep its inside sterile throughout the whole process and despite the number of operational human interactions that will take part during such period, including sampling and harvesting steps. Therefore, it is widely assumed that a bioreactor will do its part in meeting this need by assuring that the technical factors that can affect sterility, such as the lip seals, the mechanical seals, the ports accessories, among many others, are well designed and working […]

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  • Expert References

    The Dilution Rate (D) and the continuous fermentation process

    When a continuous fermentation process is carried out, it is critical that the condition of steady-state must be reached. The main process parameters that can be used for the chemostat technique are the dilution rate, specific growth rate and the yield of the product on the substrate.   The dilution rate (D), usually in units per hour (h−1), describes the relationship between the flow of medium into the bioreactor (F), that can be expressed in L·h−1, and culture volume within the bioreactor (V) in L Residence time (t) is the […]

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Ceramic Membranes with different channel number and pore size

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