bioreactors by applications
Airlift Bioreactors
For cells that are too sensitive to the shear stress and heat generation caused by the mechanical agitation, airlift bioreactors may be the most suitable solution.
Except for the agitation module, many common needs by these strains are already solved by our common bioreactor technologies. Moreover, special needs for each strain and application can be solved by the vast number of additional functional modules and PATs that Bionet’s bioreactors are able to integrate.
What are the common characteristics that microbial bioreactors share in its core design:
Microbiology vessel
There are some geometry-related variables that are important to the process outcome given their impact on the kLa and gas hold-up. These include: the bioreactor diameter and height, the draught tube diameter, its position with respect to the bioreactor’s bottom, sides and top (i.e. the so-called bottom clearance, downcomer and riser regions and top clearance), and the sparger position, etc.
An unique feature Bionet offers is the height-adjustable design of the draft tube, which enhances optimization studies and gives versality in the use of different cell types.

f0/f1 bioreactor vessel




f0/f1 bioreactor vessel




f0/f1 bioreactor vessel
Microbial processes’
relevant parameters
Airlift bioreactors hold microbial processes so most of the bioreactor conditions that have an impact on the strain’s metabolic pathway undertaken, the productivity and the product quality are also pH, dissolved oxygen (DO) and temperature. In this case the DO will transfer to the media thanks to the mixing caused by the bubbles-liquid recirculation up through the riser and down through the downcomer.
Bionet’s airlift bioreactors include the instrumentation and actuators required for the measurement and control of these parameters by default.
Moreover, these models allow for an expansion of its functionalities via the integration of optional instrumentation and actuators to the BCU (Bioreactor Control Unit) in a Plug&Play manner.
Common PATs package:
- Dissolved Oxygen (DO)
- pH
- Temperature
Common package of actuators:
- 3 peristaltic pumps (acid, base and antifoam)
- 2 gas lines (for O2 and air by default)
- Water circuit
bioprocess
software
The Airlift Bioreactors can go with ROSITA or MARTA, depending on the bioreactor model.
Both Softwares relate the information from the sensors and the actuators functioning to allow for the following features:
- Real-time visualization
- Automation
- Data registration
- Remote control




What additional functionalities can be of interest in airlift-based appications, and what technologies does Bionet provide for these?
- bBreathThe Plug&Play module you need to carry out O2/CO2 composition analysis of your bioreactor exhaust gas (i.e. metabolic predictions) and get the maximum of this data to enhance the quality and productivity of your process.
- bVSPThe Variable Speed Pump is the Plug&Play module you need to carry out substrate additions (i.e. for Fed-batch and semi-continuous processes) or withdrawal/harvesting actions according to a number of feeding/bleeding profiles.
- bCPMThe Plug&Play module you need to carry out different continuous strategies for an increase in your bioprocess productivity.
- Flexible Gas ModuleThis is the software module you need to be able to select other gas than air and O2, required for anaerobic processes or to use CO2 as an acidifying agent for pH control.
- bScaleThe bScale is the Plug&Play module that you need for the connection of scales, from a range of scale precisions and brands used in lab and production settings.
- Other Add-OnsThe Plug&Play module you need to carry out O2/CO2 composition analysis of your bioreactor exhaust gas (i.e. metabolic predictions) and get the maximum of this data to enhance the quality and productivity.
- Upstream ServicesWe reduce the "time-to-market" of new bioproducts thanks to our expertise to provide a holistic bioprocess solution. We do this by accompanying our equipment with a range of process services that help clientes to take crucial decisions and support them all the way through the selection and operation of the technologies, and the acquisition of the scientific knowledge necessary to enhance the potential of the process. This includes Upstream Proof-of-Concept Trials, Upstream Optimization Services, Bioprocess Scale-Up, Installation and training and Fermentation Courses.
- GET MORE INFO →
Microbial Bioreactor Models
Related Knowledge Hub Content
Expert References
The most common membrane modules used in the Biotech industry for Tangential Flow Filtration (TFF) are cassettes, hollow fiber and ceramic membranes. Each membrane type has certain characteristics (see Table 1) in terms of batch volume, sensibility to and with product type, and its own lifetime, that makes it more or less suitable for a […]
Expert References
The Continuous Process in the context of a bioreactor operation mode is used to prolong the production phase of a culture during its growth in a steady-state (at a constant rate and in constant conditions) to achieve higher biomass and/or metabolites amounts. There are two main process control strategies that can be implemented in Continuous […]
Expert References
5 steps into Scale-Up of Microbial Fermentation
Planning the jump into Industrial is a challenging experience that all successful bioprocesses and bioprocesists go through. With many factors having to be taken into account (at the biological, biochemical, mechanical levels among others), there is no other option than to follow a plan. What is the process information that cannot be dismissed? What process […]
BLOCKED CONTENTThis content may contain some sensistive information on a particular process or technology. Therefore, please contact us to request the material and if possible with some further information on the usage of such content.Request now
Get more info
Full Name
Write your request…