bioreactors by applications

Airlift Bioreactors

For cells that are too sensitive to the shear stress and heat generation caused by the mechanical agitation, airlift bioreactors may be the most suitable solution.

Except for the agitation module, many common needs by these strains are already solved by our common bioreactor technologies. Moreover, special needs for each strain and application can be solved by the vast number of additional functional modules and PATs that Bionet’s bioreactors are able to integrate.

What are the common characteristics that microbial bioreactors share in its core design:

Microbiology vessel

There are some geometry-related variables that are important to the process outcome given their impact on the kLa and gas hold-up. These include: the bioreactor diameter and height, the draught tube diameter, its position with respect to the bioreactor’s bottom, sides and top (i.e. the so-called bottom clearance, downcomer and riser regions and top clearance), and the sparger position, etc.

An unique feature Bionet offers is the height-adjustable design of the draft tube, which enhances optimization studies and gives versality in the use of different cell types.

f0/f1 bioreactor vessel

f0/f1 bioreactor vessel

f0/f1 bioreactor vessel

Microbial processes’
relevant parameters

Airlift bioreactors hold microbial processes so most of the bioreactor conditions that have an impact on the strain’s metabolic pathway undertaken, the productivity and the product quality are also pH, dissolved oxygen (DO) and temperature. In this case the DO will transfer to the media thanks to the mixing caused by the bubbles-liquid recirculation up through the riser and down through the downcomer.

Bionet’s airlift bioreactors include the instrumentation and actuators required for the measurement and control of these parameters by default.

Moreover, these models allow for an expansion of its functionalities via the integration of optional instrumentation and actuators to the BCU (Bioreactor Control Unit) in a Plug&Play manner.

Common PATs package:

Dissolved Oxygen (DO)
pH
Temperature

Common package of actuators:

3 peristaltic pumps (acid, base and antifoam)
2 gas lines (for O2 and air by default)
Water circuit

bioprocess
software

The Airlift Bioreactors can go with ROSITA or MARTA, depending on the bioreactor model.

Both Softwares relate the information from the sensors and the actuators functioning to allow for the following features:

Real-time visualization
Automation

Data registration
Remote control

What additional functionalities can be of interest in airlift-based appications, and what technologies does Bionet provide for these?

bBreath
The Plug&Play module you need to carry out O2/CO2 composition analysis of your bioreactor exhaust gas (i.e. metabolic predictions) and get the maximum of this data to enhance the quality and productivity of your process.
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bVSP
The Variable Speed Pump is the Plug&Play module you need to carry out substrate additions (i.e. for Fed-batch and semi-continuous processes) or withdrawal/harvesting actions according to a number of feeding/bleeding profiles.
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bCPM
The Plug&Play module you need to carry out different continuous strategies for an increase in your bioprocess productivity.
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Flexible Gas Module
This is the software module you need to be able to select other gas than air and O2, required for anaerobic processes or to use CO2 as an acidifying agent for pH control.
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bScale
The bScale is the Plug&Play module that you need for the connection of scales, from a range of scale precisions and brands used in lab and production settings.
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Other Add-Ons
The Plug&Play module you need to carry out O2/CO2 composition analysis of your bioreactor exhaust gas (i.e. metabolic predictions) and get the maximum of this data to enhance the quality and productivity.
Upstream Services
We reduce the "time-to-market" of new bioproducts thanks to our expertise to provide a holistic bioprocess solution. We do this by accompanying our equipment with a range of process services that help clientes to take crucial decisions and support them all the way through the selection and operation of the technologies, and the acquisition of the scientific knowledge necessary to enhance the potential of the process. This includes Upstream Proof-of-Concept Trials, Upstream Optimization Services, Bioprocess Scale-Up, Installation and training and Fermentation Courses.
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